DNA Antibodies

Also known as: dSDNA Antibodies; Crithidia

Anti-double stranded DNA (dsDNA) antibodies are highly sensitive and specific markers of SLE. Raised levels are found in 70 - 90% of patients with SLE and tend to correlate with disease activity. However the long half-life of IgG makes the quantitation of serum levels an insensitive measure of response to treatment. Raised levels may also be seen in a small minority of patients with chronic active hepatitis.

NB In keeping with current evidence-based guidelines, antibodies to DNA and ENA antigens will not be performed on sera that are negative for ANA.

Specimen requirements

Serum 1ml

Cost

Price on application

Laboratory turnaround time

7 days

Laboratory method

Chemiluminescence (Bioflash)

Reference range/units

Negative <27 CLU
Equivocal 27-35 CLU
Positive >35 CLU
(CLU= Chemi-Luminescence Units)

Associated tests

ANA

Sample stability

10 days at 2-8ºC

Shipping and storage

UK and Ireland

Ambient temperature and first class post. Hays DX users please enquire via email below.

International

Ambient temperature if courier will deliver within 72 hours otherwise consider refrigerated transport. Freezing is not a requirement.

Ensure delivery Monday to Friday 09:00 - 17:30.

Further information and contact details

For further information, email immunologylab.enquiries@ouh.nhs.uk