Double negative alpha/beta T cell panel

This test measures the percentage of CD3 positive alpha/beta T cells which negative for both CD4 and CD8. These cells are raised in frequency in Autoimmune Lymphoproliferative Syndrome (ALPS). ALPS is a rare disorder of lymphocyte apoptosis associated with autoimmunity and lymphoproliferation. Idiopathic thrombocytopenia purpura (ITP) and autoimmune haemolytic anaemia (AIHA) are common autoimmune phenomena in these patients.

Specimen requirements

1 mL EDTA blood must be received in the Immunology Laboratory within 48 hours of venepuncture. Samples must NOT have been refrigerated or centrifuged and must arrive before 4pm on Fridays.

Cost

Price on application

Laboratory turnaround time

3 working days

Laboratory method

FACSCanto

Reference range/units

N/A

Associated tests

TBNK

Sample stability

24 hours post venepuncture (do not refrigerate or centrifuge)

Shipping and storage

Ambient temperature and first class post. Hays DX users please enquire via email below.

Samples must be received in the Immunology Laboratory within 48 hours of venepuncture. Samples must not have been refrigerated or centrifuged and must arrive before 4.00pm on Fridays.

Further information and contact details

For further information, email immunology.office@nhs.net