Glomerular Basement Membrane Antibodies

Also known as: GBM; Goodpastures

Anti glomerular basement membrane antibodies are found in Goodpasture's syndrome and levels correlate with disease activity and often predict clinical outcome. The autoantibody is directed against the NC1 domain of the α- chain of type IV collagen. Approximately 25% of patients presenting with anti GBM antibodies also present with anti-neutrophil cytoplasmic antibodies, so parallel testing is recommended.

Specimen requirements

Serum 1ml

Cost

Price on application

Laboratory turnaround time

3 days

Laboratory method

CLiA - Automated Chemiluminescent Immunoassay

Reference range/units

2.9 - 18.9 CU = Negative

19.0 - 21.0 CU = Equivocal

> = 21.1 CU = Positive

Associated tests

ANCA

Sample stability

2 months at 2-8ºC

Shipping and storage

UK and Ireland

Ambient temperature and first class post. Hays DX users please enquire via email below.

International

Ambient temperature if courier will deliver within 72 hours otherwise consider refrigerated transport. Freezing is not a requirement.

Ensure delivery Monday to Friday 09:00 - 17:30.

Further information and contact details

For further information, email immunologylab.enquiries@ouh.nhs.uk