Immunoglobulins

Also known as: Igs; IgG; IgA; IgM; Myeloma screen

Essential investigation for 'failure to thrive', recurrent infections and lymphoproliferative diseases including myeloma. IgA deficiency occurs in 1 in 700 people and may not be associated with disease (but beware of transfusions). Polyclonal raise in IgG occurs in chronic infection and inflammation, especially HIV infection, chronic liver disease and to a lesser extent in connective tissue diseases. Reduced immunoglobulins - predominantly IgG may be due to loss (protein - losing enteropathy, nephritic syndrome), reduced synthesis (lymphoproliferative disorders; primary immune deficiency) and excessive catabolism. Low levels always warrant further investigation, as serious infective complications may occur.

Serum electrophoresis will also be performed in most cases.

Specimen requirements

Serum - 1ml

Cost

Price on application

Laboratory turnaround time

1-2 days

Laboratory method

Turbidimetry, Immunoelectrophoresis and Immunofixation

Assay interferences

Microbially contaminated, heat-treated samples should not be used.

Grossly haemolysed, icteric or lipaemic specimens should be avoided. EDTA plasma samples are contraindicated for the analysis of IgG, IgA and IgM as increased fibrinogen levels may artificially give depressed results.

Reference range/units

Normal Ranges Adult:

• IgG 6.0 - 16.0g/L
• IgA 0.8 - 3.0g/L
• IgM 0.4 - 2.5g/L

Paediatric ranges applied to children's results.

Associated tests

Serum and urine electrophoresis

Sample stability

7 days at 2-8ºC

Shipping and storage

UK and Ireland

Ambient temperature and first class post. Hays DX users please enquire via email below.

International

Ambient temperature if courier will deliver within 72 hours otherwise consider refrigerated transport. Freezing is not a requirement.

Ensure delivery Monday to Friday 09:00 - 17:30.

Further information and contact details

For further information, email immunologylab.enquiries@ouh.nhs.uk