Lymph node research pioneers' new approach to vaccine design for the most vulnerable

The Oxford Experimental Medicine Clinical Research Facility (EMCRF) has received its first volunteers as part of a clinical trial to improve vaccine design for different age groups.

Vaccines are the most effective way to prevent infectious diseases, but people respond to them in different ways. The elderly tend to respond less well as the immune system matures.

With funding from MRC/UKRI, a study team comprising University of Oxford scientists and Oxford University Hospitals (OUH) NHS Foundation Trust clinicians are conducting the LEGACY03 trial, which hopes to better understand the cause and effect of varying responses to vaccination.

The team are testing the responses of cells in lymph nodes - small bean-shaped organs found all over the body that respond to infection - before and after immunisation with flu and COVID-19 vaccines. The aim is to compare the response to these vaccines in older and younger adults.

The study focuses on volunteers aged between 18 and 45 years or 65 years and over at the time of screening. The Oxford EMCRF, which is based on the Churchill Hospital site, welcomed its first volunteers to the study in November.

The research team will harvest a small number of cells from the lymph nodes and to use ultrasound scans to observe the lymph nodes themselves. Combined with information about what is happening in the blood, the scientists hope to establish a detailed picture of how different vaccines work on different people.

Cushla Cooper, Clinical Operations Lead for the EMCRF said: "We are very excited to receive the first volunteers as part of the LEGACY03 trial. EMCRF is working alongside radiologists from Oxford University Hospitals and the study team from the Oxford Vaccine Group, to conduct these trials and deliver results. This is another great example of collaboration between Oxford University and the NHS Trust, aimed at bringing new solutions to enhance patient outcomes and we're pleased to be a part of it."

Dr Katrina Pollock of the Oxford Vaccine Group and Principal Investigator in study, said: "We have had over 700 people volunteer to be part of the study, which is a phenomenal response to our appeal. The collaborative efforts of academia, clinicians and public volunteers, in tandem with MRC and UKRI funding to support this vital study, mean we can generate meaningful results that will benefit public health globally."

Dr Rajat Chowdhury, Consultant Radiologist at OUH, said: "It is a great privilege to be working with our fantastic volunteers and within a dynamic and highly skilled multidisciplinary team of leading experts in Oxford to develop pioneering disease-preventing medicines that will help protect people all around the world."

Participants in the study receive two vaccines: an mRNA COVID-19 booster vaccine and a seasonal flu jab. The trial is being run by the Oxford Vaccine Group at the Centre for Clinical Vaccinology and Tropical Medicine, and participants are enrolled for three months. 

The results will assist researchers in designing vaccines which will offer greater protection to those most vulnerable to diseases such as flu and COVID-19.

Pictured: OUH consultant radiologist Dr Rajat Chowdhury and Dr Katrina Pollock of the Oxford Vaccine Group with a trial volunteer in the EMCR